ZELBORAF dosing

How do I take ZELBORAF?

Dosing


dosing

ZELBORAF comes in a 240-mg tablet, and the usual dose is 4 tablets twice a day. Depending on how you do on this dose, your doctor may adjust the number of pills you take per day.

How long do I take ZELBORAF?

Keep taking ZELBORAF for as long as your doctor tells you. If you need additional support, the ZELBORAF Patient Partners™ program is available 24/7.

Why is it important to take all the doses?

It is important to keep taking ZELBORAF exactly as your doctor tells you in order for your treatment to be most effective. Do not change your dose or stop taking ZELBORAF unless your doctor tells you.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is within 4 hours of your next scheduled dose, just take your next dose at your regular time. Do not make up for the missed dose. Do not take 2 doses of ZELBORAF at the same time.

Tips to help keep your treatment on track

What is ZELBORAF?

ZELBORAF is a prescription medicine used to treat a type of skin cancer called melanoma, that has spread to other parts of the body or cannot be removed by surgery, and that has a certain type of abnormal “BRAF” gene.

Your healthcare provider will perform a test to make sure that ZELBORAF is right for you.

ZELBORAF is not used to treat melanoma with a normal BRAF gene. It is not known if ZELBORAF is safe and effective in children under 18 years of age.

Important Safety Information

What is the most important information I should know about ZELBORAF?

ZELBORAF can cause serious side effects, including:

  • Risk of cancers. ZELBORAF may cause a type of skin cancer called cutaneous squamous cell carcinoma (cuSCC). New melanoma lesions have occurred in patients taking ZELBORAF. ZELBORAF may also cause another type of cancer called non-cutaneous squamous cell carcinoma (SCC). Talk with your healthcare provider about your risk for these cancers

Check your skin and tell your doctor right away about any skin changes, including a:

  • new wart
  • skin sore or reddish bump that bleeds or does not heal
  • change in size or color of a mole

Your doctor should check your skin before you start taking ZELBORAF and every 2 months while you are taking ZELBORAF to look for any new skin cancers. Your doctor may continue to check your skin for 6 months after you stop taking ZELBORAF.

Your doctor should also check for cancers that may not occur on the skin. Tell your doctor about any new symptoms that have developed while taking ZELBORAF.

What should I tell my doctor before taking ZELBORAF?

Before you start taking ZELBORAF, tell your doctor if you:

  • Have any heart problems, including a condition called long QT syndrome
  • Have liver or kidney problems
  • Have been told that you have low blood levels of potassium, calcium or magnesium
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. ZELBORAF may harm your unborn baby.
    • Females who are able to become pregnant and males who take ZELBORAF should use birth control during treatment and for 2 months after stopping ZELBORAF.
    • Talk to your doctor about birth control methods that may be right for you.
    • Tell your doctor right away if you become pregnant during treatment with ZELBORAF.
  • Are breastfeeding or plan to breastfeed. You and your doctor should decide if you will take ZELBORAF or breastfeed. You should not do both.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while taking ZELBORAF?

Avoid sunlight while you are taking ZELBORAF. ZELBORAF can make your skin sensitive to sunlight. You may burn more easily and get severe sunburns. To help protect against sunburn:

  • When you go outside, wear clothes that protect your skin including your head, face, hands, arms, and legs
  • Use lip balm and a broad-spectrum sunscreen with SPF 30 or higher.

What are the possible side effects of ZELBORAF?

  • Allergic reactions can happen while taking your ZELBORAF, and can be severe. Stop taking ZELBORAF and get medical help if you have any of these symptoms:
    • A rash or redness all over your body
    • Feel faint
    • Have trouble breathing or swallowing
    • Have throat tightness or hoarseness
    • Have a fast heartbeat
    • Have swelling of the face, lips, or tongue
  • Severe skin reactions. Stop taking ZELBORAF and call your doctor right away if you get a skin rash with any of the following symptoms because you may have a severe skin reaction:
    • Blisters on your skin
    • Blisters or sores in your mouth
    • Peeling of your skin
    • Fever
    • Redness or swelling of your face, hands, or soles of your feet
  • Changes in the electrical activity of your heart called QT prolongation. QT prolongation can cause irregular heartbeats that can be life threatening. Your doctor should do tests before you start taking ZELBORAF and during treatment with ZELBORAF to check the electrical activity of your heart. Tell your doctor right away if you feel faint, lightheaded, dizzy or feel your heart beating irregularly or fast while taking ZELBORAF. These may be symptoms related to QT prolongation
  • Abnormal liver function tests. Your doctor should do blood tests to check your liver function before you start taking ZELBORAF and during treatment. Tell your doctor right away if you get any of these symptoms of a liver problem during treatment:
    • Your skin or the whites of your eyes turn yellow
    • You feel tired
    • Your urine turns dark or brown (tea color)
    • You have nausea or vomiting
    • You do not want to eat
    • Pain on the right side of your stomach
  • Eye problems. Tell your doctor right away if you get any of these symptoms during treatment with ZELBORAF
    • Eye pain, swelling, or redness
    • Blurred vision or other vision changes during treatment with ZELBORAF

The most common side effects include:

  • Joint pain
  • Rash
  • Hair loss
  • Tiredness
  • Sunburn or sun sensitivity
  • Nausea
  • Itching
  • Warts

Tell your doctor if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of ZELBORAF. For more information about side effects, ask your doctor or pharmacist.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see full Prescribing Information and Medication Guide for additional Important Safety Information.